Tạp chí Y học Thành phố Hồ Chí Minh, 9(4):247. DOI
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Trương Thế Kỷ, Phạm Khánh Phong Lan, Nguyễn Thị Điệp
The Imidazol and Imidazoline derives have many advantages in therapy. For the synthesis of new imidazoline derives, we implemented the ethylene diamine cyclization from nitril compounds differently substituted. Then, a dehydrogenation of these imidazolines leads to the imidazol derives. The last reaction consists of the condensation of these imidazolines and imidazoles. We subjected our synthesized products to an ophthalmic protective evaluation (anti-oedema, anti-hyperemia secondary) on the experimental ocular irritancy models.
